Protein Details: P2X purinoceptor 6

Protein ID

ICDB_Pro_0186

Protein Name

P2X purinoceptor 6

Gene Name

P2RX6; P2RXL1; P2X6

Organism

Homo sapiens (Human)

Length

441 amino acids

AlphaFoldDB

AF-O15547-F1-model_v4.pdb

Function

Receptor for ATP that acts as a ligand-gated ion channel.

Sequence

MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLAKKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVESGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTATHWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQTQTPGWPCPSSDTHLPTHSGSL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome and Dental Anomalies And Short Stature

Location

Expressed predominantly in skeletal muscle

DOI ID

10.1186/gb-2004-5-10-r84; 10.1038/990031; 10.1101/gr.2596504; 10.1002/1615-9861(200206)2:6<642::aid-prot642>3.0.co;2-i; 10.1074/jbc.m412265200

RefSeq

NP_001153026.1 [O15547-2]; NP_005437.2 [O15547-1]